Prolonged Kaposi’s Sarcoma-associated Herpesvirus vIL-6 Exposure Enhances Inflammatory Responses by Epigenetic Reprogramming. ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury.
Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation. NFAT and NF-κB dynamically co-regulate TCR and CAR signaling responses in human T cells. MAX transcriptionally enhances PD-L1 to inhibit CD8+ T cell-mediated killing of lung adenocarcinoma cells.
GPX3 expression was down-regulated but positively correlated with poor outcome in human cancers. IFN-stimulated metabolite transporter ENT3 facilitates viral genome release. Transcriptome sequencing analysis reveals a potential role of lncRNA NONMMUT058932.2 and NONMMUT029203.2 in abnormal myelin development of male offspring following prenatal PM2.5 exposure. Chromatin Immunoprecipitation Sequencing (ChIP-seq) for Detecting Histone Modifications and Modifiers. The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism. Impact of FKBP52 on cell proliferation and hormone-dependent cancers. Topologically associating domain underlies tissue specific expression of long intergenic non-coding RNAs. IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression. IGF2BP1 induces high-risk neuroblastoma and forms a druggable feedforward loop with MYCN promoting 17q oncogene expression. The CKS1/CKS2 Proteostasis Axis Is Crucial to Maintain Hematopoietic Stem Cell Function. Epigenetic and transcriptional activation of the secretory kinase FAM20C as an oncogene in glioma. An Efficient Protocol for CUT&RUN Analysis of FACS-Isolated Mouse Satellite Cells. β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia. Phase Separation Modulates the Formation and Stabilities of DNA Guanine Quadruplex. Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates. SEanalysis 2.0: a comprehensive super-enhancer regulatory network analysis tool for human and mouse. A web-based integrative transcriptome analysis, RNAseqChef, uncovers cell/tissue type-dependent action of sulforaphane. Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice. Comprehensive analysis of the diagnostic and therapeutic value of the hypoxia-related gene PLAUR in the progression of atherosclerosis. Databases and prospects of dynamic gene regulation in eukaryotes: A mini review.
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ZBTB2 is Recruited to a Specific Subset of HIF-1 Target Loci to Facilitate Full Gene Expression Under Hypoxia. Mechanic Insight into the Distinct and Common Roles of Ovariectomy Versus Adrenalectomy on Adipose Tissue Remodeling in Female Mice. NPM3 as an unfavorable prognostic biomarker involved in oncogenic pathways of lung adenocarcinoma via MYC translational activation. Patterns of transcription factor binding and epigenome at promoters allow interpretable predictability of multiple functions of non-coding and coding genes. Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation.
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Transmicron: accurate prediction of insertion probabilities improves detection of cancer driver genes from transposon mutagenesis screens. Phenelzine-based probes reveal Secernin-3 is involved in thermal nociception. Stanniocalcin 2 (STC2) is a potent biomarker of hepatocellular carcinoma with its expression being augmented in Nrf1α-deficient cells, but diminished in Nrf2-deficient cells. Pan-cancer analyses reveal multi-omic signatures and clinical implementations of the forkhead-box gene family.
Gene regulatory network inference in the era of single-cell multi-omics. Pcgf1 gene disruption reveals primary involvement of epigenetic mechanism in neuronal subtype specification in the enteric nervous system. The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway. PRB inhibited cell proliferation through let-7b-E2F1 in breast cancer. Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis. C4S DB: Comprehensive Collection and Comparison for ChIP-Seq Database. ChIP-Atlas: a data-mining suite powered by full integration of public ChIP-seq data. Oki, S., Ohta, T., Shioi, G., Hatanaka, H., Ogasawara, O., Okuda, Y., Kawaji, H., Nakaki, R., Sese, J., Meno, C.ChIP-Atlas 2021 update: a data-mining suite for exploring epigenomic landscapes by fully integrating ChIP-seq, ATAC-seq and Bisulfite-seq data.
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